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- Title
Prevalence of Epstein-Barr virus in oral squamous cell carcinoma.
- Authors
Kobayashi, Ieyoshi; Shima, Kaori; Saito, Ichiro; Kiyoshima, Tamotsu; Matsuo, Kou; Ozeki, Satoru; Ohishi, Masamichi; Sakai, Hidetaka
- Abstract
Forty-six samples of oral squamous cell carcinoma (OSCC) were evaluated for the prevalence of Epstein-Barr virus (EBV) infection by the polymerase chain reaction (PCR), Southern blot hybridization, and in situ hybridization (ISH). EBV DNA was detected in 7 (15·2 per cent) out of 46 samples by a combination of PCR and Southern blot hybridization methods. All seven positive samples showed well-differentiated carcinoma, thus suggesting a possible relationship between EBV infection and the degree of differentiation of carcinoma tissue. Latent infection membrane protein 1 (LMP1) was detected immunohistochemically in six of the EBV-positive OSCCs. However, no signal of the EBV-encoded small RNA (EBER)-1 was demonstrated by the ISH method. No significant relationship was observed between EBV infection and lymph node metastasis. A follow-up study (range from 4·4 to 79 months; mean 34·9 months) showed no recurrence or death to occur in the EBV-positive patients, which thus suggested a good prognosis for EBV-positive OSCC patients. Copyright © 1999 John Wiley & Sons, Ltd.
- Publication
Journal of Pathology, 1999, Vol 189, Issue 1, p34
- ISSN
0022-3417
- Publication type
Article
- DOI
10.1002/(SICI)1096-9896(199909)189:1<34::AID-PATH391>3.0.CO;2-4