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- Title
Is the location of the signal intensity weighted centroid a reliable measurement of fluid displacement within the disc?
- Authors
Abdollah, Vahid; Parent, Eric C.; Battié, Michele C.
- Abstract
Degenerated discs have shorter T2-relaxation time and lower MR signal. The location of the signalintensity- weighted-centroid reflects the water distribution within a region-of-interest (ROI). This study compared the reliability of the location of the signal-intensity-weightedcentroid to mean signal intensity and area measurements. L4-L5 and L5-S1 discs were measured on 43 mid-sagittal T2-weighted 3T MRI images in adults with back pain. One rater analysed images twice and another once, blinded to measurements. Discs were semi-automatically segmented into a whole disc, nucleus, anterior and posterior annulus. The coordinates of the signal-intensity-weighted-centroid for all regions demonstrated excellent intraclass-correlation- coefficients for intra- (0.99-1.00) and inter-rater reliability (0.97-1.00). The standard error of measurement for the Y-coordinates of the signal-intensity-weightedcentroid for all ROIs were 0 at both levels and 0 to 2.7 mm for X-coordinates. The mean signal intensity and area for the whole disc and nucleus presented excellent intra-rater reliability with intraclass-correlation-coefficients from 0.93 to 1.00, and 0.92 to 1.00 for inter-rater reliability. The mean signal intensity and area had lower reliability for annulus ROIs, with intra-rater intraclass-correlation-coefficient from 0.5 to 0.76 and inter-rater from 0.33 to 0.58. The location of the signal-intensity-weighted-centroid is a reliable biomarker for investigating the effects of disc interventions.
- Publication
Biomedical Engineering / Biomedizinische Technik, 2018, Vol 63, Issue 4, p453
- ISSN
0013-5585
- Publication type
Article
- DOI
10.1515/bmt-2016-0178