We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dynamic Changes in Ex Vivo T-Cell Function After Viral Clearance in Chronic HCV Infection.
- Authors
Han, Ji Won; Sung, Pil Soo; Kim, Kyung Hwan; Hong, Seon-Hui; Shin, Eui-Cheol; Song, Myeong Jun; Park, Su-Hyung; Jun Song, Myeong
- Abstract
<bold>Background: </bold>Direct-acting antiviral (DAA) agents can successfully treat chronic hepatitis C virus (HCV) infection. However, the ex vivo HCV-specific T-cell function following viral clearance remains unknown.<bold>Methods: </bold>We investigated functional alterations and phenotypic changes in ex vivo HCV-specific CD8+ T cells with a longitudinal analysis of 41 patients with chronic HCV infection who were undergoing DAA treatment.<bold>Results: </bold>A patient subset exhibited a significantly increased T-cell response (mainly CD8+ T cells) at week 4 of treatment. However, this increased T-cell response diminished in later weeks. Relative to pretreatment levels, the ex vivo HCV-specific CD8+ T-cell frequency decreased at 12 weeks after the end of treatment, along with a decreased antigen-experienced CD8+ T-cell population. DAA treatment increased the proliferative capacity of HCV-specific CD8+ T cells, but this change was not correlated with ex vivo function. Patients experiencing viral breakthrough or relapse exhibited defective restoration of T-cell function.<bold>Conclusion: </bold>Our present results indicated that DAA-mediated viral clearance only transiently restored ex vivo T-cell function, suggesting a need to enhance T-cell function in DAA-treated patients.
- Publication
Journal of Infectious Diseases, 2019, Vol 219, Issue 11, pN.PAG
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiz291