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- Title
Association between the skin microbiome and lichen striatus hypopigmentation: Cutibacterium acnes as a potential cause.
- Authors
Yu, Yeuni; Lee, Byunghyuk; Shin, Kihyuk; Kim, Kihun; Lee, Hyun Jung; Shin, Jun‐Oh; Lee, Jungsoo; Kim, Hoon‐Soo; Kim, Byung‐Soo; Kim, Moon‐Bum; Kim, Yun Hak; Ko, Hyun‐Chang
- Abstract
Background: Lichen striatus (LS) is an acquired skin disorder with a linear pattern along Blaschko's lines. It commonly occurs in childhood, and the lesions spontaneously regress within several months. Objectives: Although up to 50% of LS cases exhibit hypopigmentation that can persist for several months to years, it is unknown why LS is associated with such a high incidence of hypopigmentation compared to other inflammatory skin diseases. Therefore, this study aimed to analyse the differences in the skin microbiome between LS patients with and without hypopigmentation. Methods: Differences in skin microbiome were analysed using whole genome sequencing of skin biopsies and subsequent bioinformatics analyses. Results: Some microbes commonly found in hypopigmented skin disorders, including Cutibacterium acnes, were more abundant in patients with LS showing hypopigmentation than in those not showing hypopigmentation. Conclusions: The skin microbiota may be involved in the development of hypopigmentation in LS and may be considered a treatment target to reduce LS duration and hypopigmentation.
- Subjects
CUTIBACTERIUM acnes; WHOLE genome sequencing; SKIN diseases; SKIN biopsy; BIOINFORMATICS
- Publication
Journal of the European Academy of Dermatology & Venereology, 2024, Vol 38, Issue 9, p1776
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.19746