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- Title
Virulent Klebsiella pneumoniae ST11 clone carrying bla<sub>KPC</sub> and bla<sub>NDM</sub> from patients with and without COVID-19 in Brazil.
- Authors
Pimentel, Maria Izabely Silva; Beltrão, Elizabeth Maria Bispo; Oliveira, Érica Maria de; Martins, Lamartine Rodrigues; Jucá, Moacir Batista; Lopes, Ana Catarina de Souza
- Abstract
Aims Investigated and compared the occurrence of virulence genes fimH, mrkD, irp2, entB, cps, rmpA , and wabG , resistance genes bla KPC and bla NDM, and the genetic variability and clonal relationship of 29 Klebsiella pneumoniae clinical isolates of patients with and without COVID-19, from a hospital in Brazil. Methods and results All isolates were resistant to beta-lactams. The genes were investigated by PCR, and for molecular typing, enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) and MLST were used. The detection of bla NDM was greater (n = 23) when compared to that of bla KPC (n = 14). The virulence genes that most occurred were fimH, entB, cps , and wabG , which are responsible for adhesins, siderophore enterobactin, capsule, and lipopolysaccharides, respectively. Among the isolates, 21 distinct genetic profiles were found by ERIC-PCR, with multiclonal dissemination. Four isolates belonged to the ST11 clone. Conclusions The occurrence of the ST11 is worrying as it is a high-risk clone involved in the dissemination of virulent strains throughout the world.
- Subjects
BRAZIL; COVID-19; KLEBSIELLA pneumoniae; GENETIC variation; GENETIC profile; LIPOPOLYSACCHARIDES
- Publication
Journal of Applied Microbiology, 2024, Vol 135, Issue 4, p1
- ISSN
1364-5072
- Publication type
Article
- DOI
10.1093/jambio/lxae079