We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Treatment-related esophageal stricture in pediatric patients with cancer.
- Authors
Ellenhorn, Joshua D. I.; Lambroza, Arnon; Lindsley, Karen L.; Laquaglia, Michael P.; Ellenhorn, J D; Lambroza, A; Lindsley, K L; LaQuaglia, M P
- Abstract
<bold>Background: </bold>Intensive antineoplastic regimens have enhanced long-term survival in pediatric patients with cancer, but can result in long-term complications. Esophageal stricture formation is one such complication.<bold>Methods: </bold>We reviewed the experience with benign esophageal stricture in pediatric patients with cancer over the past 15 years in a major cancer center. Clinical course, along with endoscopic, radiologic, and manometric esophageal studies, was reviewed.<bold>Results: </bold>Esophageal strictures formed in five pediatric patients who were treated with radiation and/or chemotherapy. Stricture formation was associated with abnormal esophageal motility in four out of the five patients. Repeated esophageal dilation was performed from 3-50 times and resulted in stricture resolution in only 2 of the 5 patients.<bold>Conclusions: </bold>Esophageal stricture formation in this population is rare, but is associated with long-term morbidity.
- Subjects
HODGKIN'S disease; MOUTH tumors; LYMPHOBLASTIC leukemia; MANOMETERS; RHABDOMYOSARCOMA; ANTINEOPLASTIC agents; OROPHARYNGEAL cancer; RESPIRATORY organ tumors; ESOPHAGEAL motility disorders; ESOPHAGEAL stenosis; TUMORS; RADIATION injuries; ESOPHAGUS diseases; COMBINED modality therapy; ESOPHAGEAL tumors
- Publication
Cancer (0008543X), 1993, Vol 71, Issue 12, p4084
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19930615)71:12<4084::AID-CNCR2820711246>3.0.CO;2-B