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- Title
Incomplete Immune Reconstitution after Initiation of Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus--Infected Patients with Severe CD4[sup+] Cell Depletion.
- Authors
Lederman, Howard M.; Williams, Paige L.; Wu, Julia W.; Evans, Thomas G.; Cohn, Susan E.; J. Allen McCutchan, Susan E.; Koletar, Susan L.
- Abstract
Presents a study indicating an incomplete immune reconstitution after initiation of highly active antiretroviral therapy in HIV-infected patients with severe CD4+ cell depletion. Immune function observed in HIV patients participating in the study; Median CD4+ cell count; Anergy and lack of lymphoproliferative response to tetanus toxoid after immunization and impaired antibody responses after receipt of hepatitis A and TT vaccines indicating an impaired immune reconstitution; Rate of opportunistic infections.
- Subjects
IMMUNE response; ANTIRETROVIRAL agents; HIV-positive persons; IMMUNOLOGIC diseases; HIV; COMMUNICABLE diseases
- Publication
Journal of Infectious Diseases, 2003, Vol 188, Issue 12, p1794
- ISSN
0022-1899
- Publication type
Article