We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Platelet activation in patients with sickle cell disease.
- Authors
Wun, Ted; Paglieroni, Teresa; Rangaswami, Arun; Hill Franklin, Patricia; Welborn, Jeanna; Cheung, Anthony; Tablin, Fern
- Abstract
Vascular occlusion and vasculopathy underlie much of the morbidity in patients with sickle cell anaemia. Platelets may play a role in this vasculopathy. Samples from 43 patients with sickle cell disease (SCD) were examined for evidence of platelet activation using fluorescent-labelled monoclonal antibodies and flow cytometry. There was increased expression of activation-dependent antigens on the platelets from patients with SCD compared to those from both Caucasian and African-American controls. In addition, SCD patients had increased levels of platelet microparticles. Platelets are activated in patients with sickle cell disease. The contribution of platelet activation to sickle cell pathophysiology is under active investigation in our laboratories.
- Subjects
BLOOD platelet activation; SICKLE cell anemia; PATIENTS
- Publication
British Journal of Haematology, 1998, Vol 100, Issue 4, p741
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.1998.00627.x