We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinical-associated characteristics and microbiological features of bloodstream nontyphoidal salmonella infection in adult patients receiving allogeneic hematopoietic stem cell transplantation.
- Authors
Ko, Po-Shen; Liu, Yao-Chung; Wang, Hao-Yuan; Wu, Chia-Yun; Fan, Nai-Wen; Liu, Chia-Jen; Yu, Yuan-Bin; Hsiao, Liang-Tsai; Chiou, Tzeon-Jye; Tzeng, Cheng-Hwai; Liu, Jin-Hwang; Gau, Jyh-Pyng
- Abstract
Bloodstream nontyphoidal salmonella (NTS) infection is rare, but its associated characteristics and microbiological features in immunocompromised patients are worth paying attention to, particularly for those receiving allogeneic hematopoietic stem cell transplantation (SCT). No studies so far have analyzed post-transplant bloodstream NTS infection. Therefore, we reviewed 423 adult patients undergoing allogeneic hematopoietic SCT from 2003 to 2014. Nine out of four hundred twenty-three patients (2.13%) developed post-transplant bloodstream NTS infection, including two patients who had subsequent or combined metastatic infections. The median age at SCT was 35 years (interquartile range, 29-46) among the nine patients with bloodstream NTS infection. Male patients were predominant (78%). The median onset of bloodstream NTS infection was at 315 days after SCT (range, 207-629). Multivariate analysis revealed that extensive chronic graft-versus-host disease (GVHD) (OR 8.054, p = 0.003) and nonmyeloablative transplant conditioning (OR 4.604, p = 0.037) were significant associated characteristics for NTS infection. Currently, there are no published data analyzing and exploring post-transplant bloodstream NTS infections in adult allogeneic hematopoietic SCT. Our study determined the associated characteristics and microbiological features for this infection.
- Subjects
HEMATOPOIETIC stem cell transplantation; SALMONELLA diseases; COMPLICATIONS from organ transplantation; GRAFT versus host disease; DISEASES in adults; PATIENTS; CLINICAL trials; COMPARATIVE studies; HOMOGRAFTS; IMMUNOSUPPRESSION; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SALMONELLA; SEX distribution; EVALUATION research
- Publication
Annals of Hematology, 2017, Vol 96, Issue 9, p1533
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s00277-017-3054-2