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- Title
Autologous stem cell transplantation with busulfan, cyclophosphamide, and etoposide as an intensifying frontline treatment in patients with peripheral T cell lymphomas: a multicenter retrospective trial.
- Authors
Ahn, Jae-Sook; Yang, Deok-Hwan; Jung, Sung-Hoon; Chae, Yee; Sohn, Sang; Yhim, Ho-Young; Kwak, Jae-Yong; Lee, Se-Ryeon; Kim, Yeo-Kyeoung; Kim, Hyeoung-Joon; Lee, Je-Jung
- Abstract
The effectiveness of high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) as a frontline treatment in peripheral T cell lymphomas (PTCLs) is still unclear. We retrospectively investigated the clinical outcomes of HDT/ASCT as an intensifying frontline treatment in 31 patients with newly diagnosed PTCLs. The conditioning regimen of HDT/ASCT consisted of busulfan, cyclophosphamide, and etoposide (BuCyE). At diagnosis, five (16.1 %) patients were classified as high risk according to the prognostic index for PTCL (PIT). The disease status of the patients before HDT/ASCT consisted of 23 patients (74.2 %) with complete response (CR) and eight patients (25.8 %) with partial response (PR). Six (75 %) out of eight patients with PR at pretransplantation were improved in terms of the response to CR after HDT/ASCT. At a median follow-up of 32.4 months, the 3-year probability of overall survival (OS) and progression-free survival (PFS) was 64.5 ± 8.6 %. Transplant-related mortality occurred in three patients (9.7 %), due to septic shock, hemorrhage, and delayed pneumonia, respectively. Bone marrow involvement of PTCL at diagnosis was a poor prognostic factor for OS. In conclusion, frontline HDT/ASCT with a conditioning regimen of BuCyE may be an effective and tolerable intensifying therapeutic option to improve outcomes in patients with PTCLs.
- Subjects
STEM cell transplantation; CYCLOPHOSPHAMIDE; T cells; LYMPHOMAS; MEDICAL statistics; RETROSPECTIVE studies
- Publication
Annals of Hematology, 2013, Vol 92, Issue 6, p789
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-013-1685-5