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- Title
Nodal marginal zone B-cell lymphoma: analysis of 36 cases. Clinical presentation and treatment outcomes of nodal marginal zone B-cell lymphoma.
- Authors
Oh, Sung Yong; Ryoo, Baek-Yeol; Kim, Won Seog; Kim, Kihyun; Lee, Jeeyun; Kim, Hyun Jung; Kwon, Jung Mi; Lee, Hyo Rak; Ko, Young Hye; Oh, Suk Joong; Park, Keon Woo; Kim, Hyo-Jin; Kwon, Hyuk-Chan; Nam, Eunmi; Kim, Jung Han; Park, Yeon Hee; Lee, Seung-Sook; Kim, Ho Young; Park, Keunchil
- Abstract
Nodal marginal zone B-cell lymphoma (NMZL) is a relatively uncommon type of lymphoma. Because of the rarity, the natural history and the optimal treatment modality have not been well defined. Therefore, we performed a retrospective analysis of the clinical features and treatment outcomes of NMZL. Thirty-six patients who were histologically diagnosed as NMZL were included in the analysis. Fifty-three percent of the patients had localized disease (stages I and II), and 21.2% (7/33) had bone marrow involvement at presentation. B symptom was present in only three patients (8.3%). Most patients were categorized as low or low-intermediate risk group by international prognostic index (IPI) (77.1%). Majority (94.4%) of the patients with localized disease achieved complete remission (CR) after the initial treatment. Of the seven patients with disseminated disease, who were treated with anthracycline-based chemotherapy, four patients achieved CR. Of the seven patients who received nonanthracycline-based chemotherapy, no patient achieved CR. After the median follow-up duration of 36 months, the median progression-free survival (PFS) was 3.9 (95% CI; 2.9–5.6) years, and the estimated 5-year PFS and overall survival rates were 47.2 and 82.7%, respectively. The significant predictive factors for PFS were performance status, advanced stage, and follicular lymphoma IPI (FLIPI) in this study. This clinical feature is similar to FL rather than to MZL-MALT type.
- Subjects
B cell lymphoma; LYMPHOMAS; SYMPTOMS; DRUG therapy
- Publication
Annals of Hematology, 2006, Vol 85, Issue 11, p781
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-006-0160-y