We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Antiviral Therapy Improves Survival in Hepatocellular Carcinoma with Microvascular Invasion: A Propensity Score Analysis.
- Authors
Kong, Jinfeng; Liang, Xiuhui; Zhang, Jinyu; Zeng, Jinhua; Liu, Jingfeng; Zeng, Jianxing
- Abstract
Background and Aims: To investigate the effect of postoperative adjuvant antiviral therapy (AVT) on hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) with microvascular invasion (MVI) after R0 liver resection. Methods: A total of 1008 patients with HBV-related HCC with MVI were recruited, which comprises 378 non-AVT groups and 630 AVT groups. Propensity score matching (PSM) was developed to reduce any bias in patient selection. Independent risk factors were identified by Cox regression analysis. Results: After PSM, the 1-, 3-, and 5-year overall survival rates in the AVT group and non-AVT group were 89.2%, 62.4%, 42.1%, and 73.3%, 46.3%, 22.1%, (p < 0.01), respectively. The 1-, 3-, and 5-year recurrence-free survival rates in the AVT group and non-AVT group were 52.5%, 30.4%, 22.1%, and 46.3%, 26.8%, 13.2% (p = 0.02), respectively. Multivariate Cox analysis revealed that postoperative adjuvant AVT was the independent protective factor associated with mortality (HR = 0.55, 95%CI = 0.46–0.67, p < 0.01) and tumor recurrence (HR = 0.81, 95%CI = 0.69–0.96, p = 0.01). Conclusions: Among patients who underwent curative hepatectomy for HBV-related HCC with MVI, postoperative adjuvant AVT was the independent protective factor associated with mortality and tumor recurrence. Given the high rate of postoperative recurrence and poor prognosis of HBV-related HCC with MVI, our findings may have useful clinical significance in the prevention of tumor recurrence in these patients.
- Subjects
HEPATOCELLULAR carcinoma; LIVER surgery; HEPATITIS B virus; PROPENSITY score matching; DISEASE relapse; PATIENT selection
- Publication
Digestive Diseases & Sciences, 2022, Vol 67, Issue 8, p4250
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-021-07248-z