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- Title
Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer's disease with PET imaging agents <sup>18</sup>F-flutemetamol and <sup>18</sup>F-florbetaben.
- Authors
Son, Hye Joo; Jeong, Young Jin; Yoon, Hyun Jin; Lee, Sang Yoon; Choi, Go-Eun; Park, Ji-Ae; Kim, Min Hwan; Lee, Kyo Chul; Lee, Yong Jin; Kim, Mun Ki; Cho, Kook; Kang, Do-Young
- Abstract
<bold>Background: </bold>Although amyloid beta (Aβ) imaging is widely used for diagnosing and monitoring Alzheimer's disease in clinical fields, paralleling comparison between 18F-flutemetamol and 18F-florbetaben was rarely attempted in AD mouse model. We performed a comparison of Aβ PET images between 18F-flutemetamol and 18F-florbetaben in a recently developed APPswe mouse model, C57BL/6-Tg (NSE-hAPPsw) Korl.<bold>Results: </bold>After an injection (0.23 mCi) of 18F-flutemetamol and 18F-florbetaben at a time interval of 2-3 days, we compared group difference of SUVR and kinetic parameters between the AD (n = 7) and control (n = 7) mice, as well as between 18F-flutemetamol and 18F-florbetaben image. In addition, bio-distribution and histopathology were conducted. With visual image and VOI-based SUVR analysis, the AD group presented more prominent uptake than did the control group in both the 18F-florbetaben and 18F-flutemetamol images. With kinetic analysis, the 18F-florbetaben images showed differences in K1 and k4 between the AD and control groups, although 18F-flutemetamol images did not show significant difference. 18F-florbetaben images showed more prominent cortical uptake and matched well to the thioflavin S staining images than did the 18F-flutemetamol image. In contrast, 18F-flutemetamol images presented higher K1, k4, K1/k2 values than those of 18F-florbetaben images. Also, 18F-flutemetamol images presented prominent uptake in the bowel and bladder, consistent with higher bio-distribution in kidney, lung, blood and heart.<bold>Conclusions: </bold>Compared with 18F-flutemetamol images, 18F-florbetaben images showed prominent visual uptake intensity, SUVR, and higher correlations with the pathology. In contrast, 18F-flutemetamol was more actively metabolized than was 18F-florbetaben (Son et al. in J Nucl Med 58(Suppl 1):S278, 2017].
- Subjects
ALZHEIMER'S disease; AMYLOID; BOWEL &; bladder training; INTESTINAL diseases; PATHOLOGY
- Publication
BMC Neuroscience, 2018, Vol 19, Issue 1, pN.PAG
- ISSN
1471-2202
- Publication type
journal article
- DOI
10.1186/s12868-018-0447-7