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- Title
Bisphosphonate-associated osteonecrosis of the jaw,with healing after teriparatide:a review of the literature and a case report.
- Authors
Narongroeknawin, Pongthorn; Danila, Maria I.; Humphreys Jr., Lewis G.; Barasch, Andrei; Curtis, Jeffrey R.
- Abstract
This paper reports the case history of a patient who had bisphosphonate-associated osteonecrosis of the jaw (ONJ) in which adjunctive treatment with teriparatide was used. The patient was treated for 5 years with alendronate for osteoporosis and developed ONJ after extraction of maxillary teeth. An implant was placed at the site of the extracted teeth. The pathology report confirmed the clinical diagnosis of ONJ; treatment was changed from alendronate to teriparatide and the ONJ resolved. To our knowledge, this is the third case history reported in the literature in which teriparatide was successfully used as adjunct therapy in ONJ because it has an anabolic effect and presumed role in accelerating bone healing. ONJ is a serious but infrequent condition that has been recently associated with nitrogen-containing bisphosphonate therapy. Teriparatide may be a useful adjunctive therapy when ONJ develops.
- Subjects
OSTEONECROSIS; JAW diseases; DIPHOSPHONATES; OSTEOPOROSIS; DENTAL extraction
- Publication
Special Care in Dentistry, 2010, Vol 30, Issue 2, p77
- ISSN
0275-1879
- Publication type
Article
- DOI
10.1111/j.1754-4505.2009.00128.x