We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of Casein-Derived Peptide Met-Lys-Pro on Systolic and Diastolic Blood Pressure: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
- Authors
Sato, Soichiro; Ochi, Daisuke; Nabeshima, Kazumi; Sakiyama, Ryo; Somoto, Yuki; Nakano, Manabu; Tanaka, Miyuki; Nakamura, Masahiko
- Abstract
Hypertension is defined as a systolic blood pressure (SBP) of over 140 mmHg or diastolic blood pressure (DBP) of over 90 mmHg. Hypertension is widely known to be a factor affecting human health, so its prevention is considered important. We investigated the effect of casein-derived tripeptide Met-Lys-Pro (MKP) on blood pressure in a randomized, placebo-controlled, parallel-group study. Participants were healthy adults with SBP between 120 and 139 mmHg, and/or DBP between 80 and 89 mmHg. A total of 121 participants were randomly assigned to the MKP group or placebo group. Participants received either a test powder containing 100 μg of MKP or a placebo powder without MKP for 12 weeks. As a result, SBP and DBP were significantly lower in the MKP group than in the placebo group. No adverse events associated with the MKP intake were observed. This study showed that MKP has a beneficial effect on lowering blood pressure in healthy adults with high-normal and elevated blood pressure and can be safely used for continuous intake.
- Subjects
PLACEBOS; RESEARCH funding; HYPERTENSION; CASEINS; OLIGOPEPTIDES; STATISTICAL sampling; BLIND experiment; POWDERS; ANTIHYPERTENSIVE agents; TREATMENT effectiveness; RANDOMIZED controlled trials; DESCRIPTIVE statistics; DIASTOLIC blood pressure; SYSTOLIC blood pressure
- Publication
Nutrients, 2024, Vol 16, Issue 17, p2975
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16172975