We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Inhibitory effect of human indoleamine 2,3-dioxygenase 1 (hIDO1) by kazinols of 1,3-diphenylpropane derivatives.
- Authors
Oh, Taehoon; Jung, Sunin; Oh, Seon Min; Park, Mi Hyeon; Kim, Hyoung-Geun; Lee, Su-Yeon; Ko, Sung-Kyun; Ryu, Hyung Won
- Abstract
This study focused on identifying and characterizing 1,3-diphenylpropane derivatives from flavonoids that inhibit human indoleamine 2,3-dioxygenase 1 (hIDO1) enzymes, which play a role in immune regulation and are associated with various diseases. A series of isolated metabolites (1–7) demonstrated modest to high inhibition of hIDO1, with binding degree values ranging from 26.31 to 72.17%. In particular, during a target-based screening of natural products using hIDO1, kazinol J (6, a 1,3-diphenylpropane derivative) was found to potently inhibit hIDO1, with a binding degree of 72.17% at 1 ppm. Kazinol J (6) showed concentration-dependent and mixed inhibition kinetics and achieved slow and time-dependent inhibition of hIDO1. Additionally, docking simulations were performed to evaluate the inhibitory potential and binding interactions of the compounds with hIDO1. These findings suggest that these 1,3-diphenylpropane derivatives can serve as therapeutic agents for conditions involving hIDO1 dysregulation, such as cancer, autoimmune disorders, and infectious diseases.
- Subjects
INDOLEAMINE 2,3-dioxygenase; AUTOIMMUNE diseases; NATURAL products; COMMUNICABLE diseases; ULTRAFILTRATION
- Publication
Applied Biological Chemistry, 2024, Vol 67, Issue 1, p1
- ISSN
2468-0834
- Publication type
Article
- DOI
10.1186/s13765-024-00923-5