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- Title
Hsa_circ_ROBO1 competes with miR-324-3p and upregulates NME1 to promote tumor metastasis in nasopharyngeal carcinoma.
- Authors
Liang, FenFeng; Zhao, Hai; Liu, GengChun; Huang, MeiLing; Peng, ZhengJia
- Abstract
Background: This work aims to explore circ_ROBO1's function in nasopharyngeal carcinoma (NPC). Methods: circ_ROBO1 expression in NPC tissues and cell lines was measured. The regulation of circ_ROBO1 and/or miR-324-3p on the proliferation, migration, invasion, and apoptosis of NPC cells was investigated by functional experiments. The interplay between circ_ROBO1, miR-324-3p, and NME1 was explored. Tumor growth and metastasis were studied in mice. Results: circ_ROBO1 was overexpressed in NPC. Knockdown of circ_ROBO1 repressed proliferation, migration, and invasion and induced apoptosis of NPC cells. Loss of circ_ROBO1 reduced tumor growth and metastasis in mice. circ_ROBO1 competed with miR-324-3p to upregulate NME1. Lowering miR-324-3p expression impaired the effect of knockdown of circ_ROBO1on NPC cells. Conclusion: Overexpressed circ_ROBO1 promotes NPC development by modifying the miR-324-3p/NME1 axis.
- Subjects
NASOPHARYNX cancer; METASTASIS; TUMOR growth; CELL lines; APOPTOSIS
- Publication
Discover Oncology, 2024, Vol 15, Issue 1, p1
- ISSN
2730-6011
- Publication type
Article
- DOI
10.1007/s12672-024-01220-9