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- Title
Hollow CeO<sub>2</sub>‐Based Nanozyme with Self‐Accelerated Cascade Reactions for Combined Tumor Therapy.
- Authors
Meng, Lili; Tang, Lingxue; Gao, Fangli; Zhu, Liang; Liu, Xinhe; Zhang, Jie; Chang, Yi; Ma, Xiaoming; Guo, Yuming
- Abstract
Nanozymes have obvious advantages in improving the efficiency of cancer treatment. However, due to the lack of tissue specificity, low catalytic efficiency, and so on, their clinical applications are limited. Herein, the nanoplatform CeO2@ICG@GOx@HA (CIGH) with self‐accelerated cascade reactions is constructed. The as‐prepared nanozyme shows the superior oxidase (OXD)‐like, superoxide dismutase (SOD)‐like, catalase (CAT)‐like and peroxidase (POD)‐like activities. At the same time, under 808 nm near‐infrared (NIR) irradiation, the photodynamic and photothermal capabilities are also significantly enhanced due to the presence of indocyanine green (ICG). We demonstrate that the nanozyme CIGH can efficiently accumulate in the tumor and exhibit amplified cascade antitumor effects with negligible systemic toxicity through the combination of photodynamic therapy (PDT), photothermal therapy (PTT), chemodynamic therapy (CDT) and starvation therapy. The nanozyme prepared in this study provides a promising candidate for catalytic nanomedicines for efficient tumor therapy.
- Subjects
PHOTODYNAMIC therapy; SUPEROXIDE dismutase; INDOCYANINE green; SYNTHETIC enzymes; CANCER treatment
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 49, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202401640