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- Title
Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review.
- Authors
Hassan, Mubashir; Shahzadi, Saba; Yasir, Muhammad; Chun, Wanjoo; Kloczkowski, Andrzej
- Abstract
Chronic pain is frequently associated with neuropathy, inflammation, or the malfunctioning of nerves. Chronic pain is associated with a significant burden of morbidity due to opioid use, associated with addiction and tolerance, and disability. MicroRNAs (miRs) are emerging therapeutic targets to treat chronic pain through the regulation of genes associated with inflammation, neuronal excitability, survival, or de-differentiation. In this review, we discuss the possible involvement of miRs in pain-related molecular pathways. miRs are known to regulate high-conviction pain genes, supporting their potential as therapeutic targets.
- Subjects
NOCICEPTORS; CHRONIC pain; PAIN management; DRUG target; GENETIC regulation
- Publication
Genes, 2024, Vol 15, Issue 8, p1003
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes15081003