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- Title
Heat-Processed Soybean Germ Extract and Lactobacillus gasseri NK109 Supplementation Reduce LPS-Induced Cognitive Impairment and Colitis in Mice.
- Authors
Yun, Soo-Won; Lee, Dong-Yun; Park, Hee-Seo; Kim, Dong-Hyun
- Abstract
Soybean alleviates cognitive impairment. In our preparatory experiment, we found that dry-heat (90 °C for 30 min)-processed soybean embryo ethanol extract (hSE) most potently suppressed lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α expression in BV2 cells among dry-heat-, steaming-, and oil exclusion-processed soybean embryo ethanol extracts (SEs). Heat processing increased the absorbable soyasaponin Bb content of SE. Therefore, we investigated whether hSE and its supplement could mitigate LPS-impaired cognitive function in mice. Among dry-heat-, steaming-, and oil exclusion-processed SEs, hSE mitigated LPS-impaired cognitive function more than parental SE. hSE potently upregulated LPS-suppressed brain-derived neurotropic factor (BDNF) expression in the hippocampus, while LPS-induced TNF-α and IL-1β expression in the hippocampus and colon were downregulated. Lactobacillus gasseri NK109 additively increased the cognitive function-enhancing activity of hSE in mice with LPS-induced cognitive impairment as follows: the hSE and NK109 mix potently increased cognitive function and hippocampal BDNF expression and BDNF-positive neuron cell numbers and decreased TNF-α expression and NF-κB-positive cell numbers in the hippocampus and colon. These findings suggest that hSE and its supplement may decrease colitis and neuroinflammation by suppressing NF-κB activation and inducing BDNF expression, resulting in the attenuation of cognitive impairment.
- Subjects
THERAPEUTIC use of probiotics; COLITIS prevention; NF-kappa B; RESEARCH funding; NEURONS; SOYBEAN; NEUROINFLAMMATION; PLANT extracts; HEAT; MICE; COLON (Anatomy); LIPOPOLYSACCHARIDES; COGNITION disorders; LACTOBACILLUS; ANIMAL experimentation; GLYCOSIDES; BRAIN-derived neurotrophic factor; HIPPOCAMPUS (Brain); TUMOR necrosis factors; INTERLEUKINS; COGNITION
- Publication
Nutrients, 2024, Vol 16, Issue 16, p2736
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16162736