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- Title
miR-4306 Suppresses Proliferation of Esophageal Squamous Cell Carcinoma Cell by Targeting SIX3.
- Authors
Yang, Chengyuan; Guo, Zichan; Zhao, Zitong; Wei, Yuan; Wang, Xiaoxia; Song, Yongmei
- Abstract
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and the primary cause of cancer-related mortality in China. micoRNA plays a vital role during tumor initiation and malignant progression. miR-4306 has been reported to negatively regulate aggressive cell phenotypes in triple-negative breast cancer (TNBC). Nevertheless, the function of miR-4306 in ESCC was still not clear. In this study, we detected miR-4306 expression by quantitative real-time reverse transcription-PCR (qRT-PCR) and found that miR-4306 expression was downregulated in human ESCC tissue samples and cell lines. Moreover, miR-4306 overexpression could restrain ESCC cell proliferation, migratory and invasive ability and epithelial-mesenchymal transition (EMT), promote cell apoptosis after treatment with or without cisplatin. In contrast, inhibiting the expression of miR-4306 showed the opposing results. Furthermore, we explored the molecular mechanism of effects of miR-4306 and found that miR-4306 inhibited the expression of SIX3 by interaction with SIX3 3′UTR in ESCC cells, and SIX3 overexpression significantly reversed the effect of miR-4306-mediated ESCC cells proliferation. The current study provided evidence of miR-4306 as a tumor suppression gene in ESCC.
- Subjects
CHINA; SQUAMOUS cell carcinoma; TRIPLE-negative breast cancer; GENE silencing; EPITHELIAL-mesenchymal transition; CANCER-related mortality
- Publication
Cell Biochemistry & Biophysics, 2021, Vol 79, Issue 4, p769
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-021-00994-x