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- Title
α-Tocotrienol in rice bran enhances steroidogenesis in mouse Leydig cell via increased gene expression of steroidogenic acute regulatory protein and induction of its mitochondrial translocation.
- Authors
Terada, Naofumi; Nagase, Tomoaki; Kayooka, Hiromi; Adachi, Yusuke; Kato, Eisuke
- Abstract
Rice is a staple food in the Asian region and one of the world's major energy sources. Testosterone is a steroid hormone that maintains physical, sexual, and cognitive ability, and its decline causes health problems like late-onset hypogonadism. Evaluation of various grain extracts showed rice bran to stimulate testosterone secretion from Leydig model cells. α-Tocotrienol was found as a bioactive compound in rice bran, and mechanistic analysis showed the stimulation of steroid hormone synthesis through enhanced gene expression of steroidogenic acute regulatory protein as well as inducing mitochondrial localization of the protein. Preliminary study showed an increasing trend in serum testosterone levels in mice by oral intake of α-tocotrienol. These results suggest that α-tocotrienol intake may be effective in preventing symptoms caused by low testosterone levels.
- Subjects
STEROIDOGENIC acute regulatory protein; RICE bran; LEYDIG cells; GENE expression; HORMONE synthesis; STEROID synthesis
- Publication
Bioscience, Biotechnology & Biochemistry, 2024, Vol 88, Issue 2, p189
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1093/bbb/zbad153