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- Title
Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract.
- Authors
Verma, Preeti; Sharma, Priyanka; Parmar, Jyoti; Agrawal, Annapurna; Goyal, P.K.
- Abstract
Background. This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver. Results. Radiation exposure resulted in a significant decline (P < .001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood. Maximum changes in all the parameters were observed on day 3 after irradiation. In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals. Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls. Conclusion. From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice.
- Subjects
THERAPEUTIC use of ginseng; RADIATION injuries; THERAPEUTIC use of plant extracts; ERYTHROCYTES; ANALYSIS of variance; ANIMAL experimentation; BLOOD; GINSENG; GLUTATHIONE; HEMATOCRIT; HEMOGLOBINS; LIVER; LIPID peroxidation (Biology); MICE; RADIATION-protective agents; TIME; QUALITATIVE research; QUANTITATIVE research; PREVENTION
- Publication
Integrative Cancer Therapies, 2011, Vol 10, Issue 1, p77
- ISSN
1534-7354
- Publication type
Article
- DOI
10.1177/1534735410375098