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- Title
Cherenkov Radiation‐Mediated In Situ Excitation of Discrete Luminescent Lanthanide Complexes.
- Authors
Cosby, Alexia G.; Ahn, Shin Hye; Boros, Eszter
- Abstract
Lanthanide luminescence, while ideal for in vivo applications owing to sharp emission bands within the optical window, requires high‐intensity, short‐wavelength excitation of small organic "antenna" chromophores in the vicinity of the lanthanide complex to access excited f‐orbital states through intersystem crossing. Herein, we explored Cherenkov radiation of the radioisotopes 18F and 89Zr as an in situ source of antenna excitation. The effective inter‐ and intramolecular excitation of the terbium(III) complexes of a macrocylic polyaminocarboxylate ligand (hydration number (q)=0, quantum yield (φ)=47 %) as well as its analogue functionalized to append an intramolecular Cherenkov excitation source (q=0.07, φ=63 %) was achieved. Using conventional small‐animal fluorescence imaging equipment, we have determined a detection limit of 2.5 nmol of Tb(III) complex in presence of 10 μCi of 18F or 89Zr. Our system is the first demonstration of the optical imaging of discrete luminescent lanthanide complexes without external short‐wave excitation.
- Subjects
CHERENKOV radiation; LUMINESCENCE; RARE earth metals; CHROMOPHORES; TERBIUM
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 47, p15722
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201809783