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- Title
Palladium‐Catalyzed Reductive [5+1] Cycloaddition of 3‐Acetoxy‐1,4‐enynes with CO: Access to Phenols Enabled by Hydrosilanes.
- Authors
Wu, Li‐Jun; Song, Ren‐Jie; Luo, Shenglian; Li, Jin‐Heng
- Abstract
Abstract: A new palladium‐catalyzed reductive [5+1] cycloaddition of 3‐acetoxy‐1,4‐enynes with CO, enabled by hydrosilanes, has been developed for delivering valuable functionalized phenols. This methodology employs hydrosilanes as the external reagent to facilitate the [5+1] carbonylative benzannulation. The reaction is a conceptually and mechanistically novel carbonylative cycloaddition route for the construction of substituted phenols, through the formation of four new chemical bonds, with excellent functional‐group tolerance.
- Subjects
PALLADIUM catalysts; RING formation (Chemistry); ENYNES; CARBON monoxide; CARBONYLATION; PHENOLS
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 40, p13492
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201808388