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- Title
Enzyme‐Compatible Dynamic Nanoreactors from Electrostatically Bridged Like‐Charged Surfactants and Polyelectrolytes.
- Authors
Thiele, Martin J.; Davari, Mehdi D.; Hofmann, Isabell; König, Melanie; Lopez, Carlos G.; Vojcic, Ljubica; Richtering, Walter; Schwaneberg, Ulrich; Tsarkova, Larisa A.
- Abstract
Abstract: Reported is an unanticipated mechanism of attractive electrostatic interactions of fully neutralized polyacrylic acid (PAA) with like‐charged surfactants. Amphiphilic polymer‐surfactant complexes with high interfacial activity and a solubilization capacity exceeding that of conventional micelles are formed by bridging with Ca2+ ions. Incorporation of a protease into such dynamic nanoreactors results in a synergistically enhanced cleaning performance because of the improved solubilization of poorly water‐soluble immobilized proteins. Competitive interfacial and intermolecular interactions on different time‐ and length‐scales have been resolved using colorimetric analysis, dynamic tensiometry, light scattering, and molecular dynamic simulations. The discovered bridging association mechanism suggests reengineering of surfactant/polymer/enzyme formulations of modern detergents and opens new opportunities in advancing labile delivery systems.
- Subjects
ENZYME analysis; SURFACE active agents; POLYELECTROLYTES; COLORIMETRIC analysis; ANALYTICAL chemistry
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 30, p9546
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201805021