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- Title
Palladium‐Catalyzed Enantioselective C−H Olefination of Diaryl Sulfoxides through Parallel Kinetic Resolution and Desymmetrization.
- Authors
Zhu, Yu‐chao; Li, Yan; Zhang, Bo‐chao; Zhang, Feng‐xu; Yang, Yi‐nuo; Wang, Xi‐sheng
- Abstract
Abstract: The first example of PdII‐catalyzed enantioselective C−H olefination with non‐chiral or racemic sulfoxides as directing groups was developed. A variety of chiral diaryl sulfoxides were synthesized with high enantioselectivity (up to 99 %) through both desymmetrization and parallel kinetic resolution (PKR). This is the first report of PdII‐catalyzed enantioselective C(sp2)−H functionalization through PKR, and it represents a novel strategy to construct sulfur chiral centers.
- Subjects
ENANTIOSELECTIVE catalysis; OLEFINATION reactions; PALLADIUM catalyst reactivity; SULFOXIDES; KINETIC resolution
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 18, p5223
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201801146