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- Title
Dendronized Semiconducting Polymer as Photothermal Nanocarrier for Remote Activation of Gene Expression.
- Authors
Lyu, Yan; Cui, Dong; Sun, He; Miao, Yansong; Duan, Hongwei; Pu, Kanyi
- Abstract
Regulation of transgene systems is needed to develop innovative medicines. However, noninvasive remote control of gene expression has been rarely developed and remains challenging. We herein synthesize a near-infrared (NIR) absorbing dendronized semiconducting polymer (DSP) and utilize it as a photothermal nanocarrier not only to efficiently deliver genes but also to spatiotemporally control gene expression in conjunction with heat-inducible promoter. DSP has a high photothermal conversion efficiency (44.2 %) at 808 nm, permitting fast transduction of NIR light into thermal signals for intracellular activation of transcription. Such a DSP-mediated remote activation can rapidly and safely result in 25- and 4.5-fold increases in the expression levels of proteins in living cells and mice, respectively. This study thus provides a promising approach to optically regulate transgene systems for on-demand therapeutic transgene dosing.
- Subjects
POLYMERS; NANOCARRIERS; PHOTOTHERMAL effect; GENE expression; TRANSGENES; REMOTE control
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 31, p9283
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201705543