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- Title
A Copper-Catalyzed Decarboxylative Amination/Hydroamination Sequence: Switchable Synthesis of Functionalized Indoles.
- Authors
Li, Tian ‐ Ren; Cheng, Bei ‐ Yi; Wang, Ya ‐ Ni; Zhang, Mao ‐ Mao; Lu, Liang ‐ Qiu; Xiao, Wen ‐ Jing
- Abstract
A copper-catalyzed decarboxylative amination/hydroamination sequence of propargylic carbamates with various nucleophiles is described for the first time. It features an earth-abundant metal catalyst, mild reaction conditions, and high efficiency. Further treatments of the resultant key intermediates using an acid or a base in one pot enable the controllable and divergent synthesis of two types of functionalized indoles. Moreover, experiments to demonstrate the synthetic potential of this methodology are performed.
- Subjects
INDOLE; HETEROCYCLIC compounds synthesis; AMINATION; CARBAMATES; NUCLEOPHILES; METAL catalysts; INTERMEDIATES (Chemistry)
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 40, p12610
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201605900