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- Title
Palladium(0)-Catalyzed Iminohalogenation of Alkenes: Synthesis of 2-Halomethyl Dihydropyrroles and Mechanistic Insights into the Alkyl Halide Bond Formation.
- Authors
Chen, Chen; Hou, Longlei; Cheng, Mian; Su, Jianhua; Tong, Xiaofeng
- Abstract
Although the advances on carbon halide reductive elimination have been made, the alkyl bromide and chloride analogues remain a challenge. Here, a palladium(0)-catalyzed iminohalogenation of γ,δ-unsaturated oxime esters is described, and the use of electron-poor phosphine ligands proved to be crucial to promoting alkyl bromide and chloride reductive elimination. Furthermore, SN2-type alkyl bromide and chloride reductive elimination has also been established.
- Subjects
PALLADIUM catalysts; HALOGENATION; HALOALKANES; ALKYL bromides; PHOSPHINE; OXIMES
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 10, p3135
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201410996