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Oxy210, a Semi-Synthetic Oxysterol, Inhibits Profibrotic Signaling in Cellular Models of Lung and Kidney Fibrosis.
Published in:
Pharmaceuticals (14248247), 2023, v. 16, n. 1, p. 114, doi. 10.3390/ph16010114
By:
- Wang, Feng;
- Stappenbeck, Frank;
- Parhami, Farhad
Publication type:
Article
Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 10, p. 5478, doi. 10.3390/ijms23105478
By:
- Wang, Feng;
- Stappenbeck, Frank;
- Tang, Liu-Ya;
- Zhang, Ying E.;
- Hui, Simon T.;
- Lusis, Aldons J.;
- Parhami, Farhad
Publication type:
Article
Bone Density and Hyperlipidemia: The T-lymphocyte Connection.
Published in:
Journal of Bone & Mineral Research, 2010, v. 25, n. 11, p. 2460, doi. 10.1002/jbmr.148
By:
- Graham, Lucia S.;
- Tintut, Yin;
- Parhami, Farhad;
- Kitchen, Christina M. R.;
- Ivanov, Yevgeniv;
- Tetradis, Sotirios;
- Effros, Rita B.
Publication type:
Article
Osteogenic Oxysterol, 20(S)-Hydroxycholesterol, Induces Notch Target Gene Expression in Bone Marrow Stromal Cells.
Published in:
Journal of Bone & Mineral Research, 2010, v. 25, n. 4, p. 782, doi. 10.1359/jbmr.091024
By:
- Kim, Woo-Kyun;
- Meliton, Vicente;
- Tetradis, Sotiros;
- Weinmaster, Gerry;
- Hahn, Theodore J.;
- Carlson, Marc;
- Nelson, Stanley F.;
- Parhami, Farhad
Publication type:
Article
20(S)-Hydroxycholesterol Inhibits PPARγ Expression and Adipogenic Differentiation of Bone Marrow Stromal Cells Through a Hedgehog-Dependent Mechanism.
Published in:
Journal of Bone & Mineral Research, 2007, v. 22, n. 11, p. 1711, doi. 10.1359/JBMR.070710
By:
- Woo-Kyun Kim;
- Meliton, Vicente;
- Amantea, Christopher M.;
- Hahn, Theodore J.;
- Parhami, Farhad
Publication type:
Article
Oxysterols Regulate Differentiation of Mesenchymal Stem Cells: Pro-Bone and Anti-Fat.
Published in:
Journal of Bone & Mineral Research, 2004, v. 19, n. 5, p. 830, doi. 10.1359/jbmr.040115
By:
- Kha, Hoa Ton;
- Basseri, Benjamin;
- Shouhed, Daniel;
- Richardson, Jennifer;
- Tetradis, Sotirios;
- Hahn, Theodore J;
- Parhami, Farhad
Publication type:
Article
Role of the Cholesterol Biosynthetic Pathway in Osteoblastic Differentiation of Marrow Stromal Cells.
Published in:
Journal of Bone & Mineral Research, 2002, v. 17, n. 11, p. 1997, doi. 10.1359/jbmr.2002.17.11.1997
By:
- Parhami, Farhad;
- Mody, Nilam;
- Gharavi, Nima;
- Ballard, Alex J.;
- Tintut, Yin;
- Demer, Linda L.
Publication type:
Article
Atherogenic High-Fat Diet Reduces Bone Mineralization in Mice.
Published in:
Journal of Bone & Mineral Research, 2001, v. 16, n. 1, p. 182, doi. 10.1359/jbmr.2001.16.1.182
By:
- Parhami, Farhad;
- Tintut, Yin;
- Beamer, Wesley G.;
- Gharavi, Nima;
- Goodman, William;
- Demer, Linda L.
Publication type:
Article
Atherogenic Diet and Minimally Oxidized Low Density Lipoprotein Inhibit Osteogenic and Promote Adipogenic Differentiation of Marrow Stromal Cells.
Published in:
Journal of Bone & Mineral Research, 1999, v. 14, n. 12, p. 2067, doi. 10.1359/jbmr.1999.14.12.2067
By:
- Parhami, Farhad;
- Jackson, Simon M.;
- Tintut, Yin;
- Le, Vien;
- Balucan, Jennifer P.;
- Territo, Mary;
- Demer, Linda L.
Publication type:
Article
Effect of Oxy133, an osteogenic oxysterol, on new bone formation in rat two-level posterolateral fusion model.
Published in:
2017
By:
- Buser, Zorica;
- Drapeau, Susan;
- Stappenbeck, Frank;
- Pereira, Renata;
- Parhami, Farhad;
- Wang, Jeffrey;
- Pereira, Renata C;
- Wang, Jeffrey C
Publication type:
journal article
Nuclear receptor profile in calvarial bone cells undergoing osteogenic versus adipogenic differentiation.
Published in:
Journal of Cellular Biochemistry, 2008, v. 105, n. 5, p. 1316, doi. 10.1002/jcb.21931
By:
- Pirih, Flavia Q.;
- Abayahoudian, Rosette;
- Elashoff, David;
- Parhami, Farhad;
- Nervina, Jeanne M.;
- Tetradis, Sotirios
Publication type:
Article
Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling.
Published in:
Journal of Cellular Biochemistry, 2008, v. 105, n. 2, p. 424, doi. 10.1002/jcb.21840
By:
- Amantea, Christopher M.;
- Kim, Woo-Kyun;
- Meliton, Vicente;
- Tetradis, Sotirios;
- Parhami, Farhad
Publication type:
Article
Oxysterol-induced osteoblastic differentiation of pluripotent mesenchymal cells is mediated through a PKC- and PKA-dependent pathway.
Published in:
Journal of Cellular Biochemistry, 2007, v. 100, n. 5, p. 1131, doi. 10.1002/jcb.21112
By:
- Richardson, Jennifer A.;
- Amantea, Christopher M.;
- Kianmahd, Benjamin;
- Tetradis, Sotirios;
- Lieberman, Jay R.;
- Hahn, Theodore J.;
- Parhami, Farhad
Publication type:
Article
Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells.
Published in:
Journal of Cellular Biochemistry, 2005, v. 95, n. 6, p. 1276, doi. 10.1002/jcb.20497
By:
- Daniel Shouhed;
- Hoa Ton Kha;
- Jennifer A. Richardson;
- Christopher M. Amantea;
- Theodore J. Hahn;
- Farhad Parhami
Publication type:
Article
Oxy210, a novel inhibitor of hedgehog and TGF‐β signalling, ameliorates hepatic fibrosis and hypercholesterolemia in mice.
Published in:
Endocrinology, Diabetes & Metabolism, 2021, v. 4, n. 4, p. 1, doi. 10.1002/edm2.296
By:
- Hui, Simon T.;
- Wang, Feng;
- Stappenbeck, Frank;
- French, Samuel W.;
- Magyar, Clara E.;
- Parhami, Farhad;
- Lusis, Aldons J.
Publication type:
Article
Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol.
Published in:
Journal of Cellular Biochemistry, 2017, v. 118, n. 3, p. 499, doi. 10.1002/jcb.25668
By:
- Wang, Feng;
- Stappenbeck, Frank;
- Matsui, William;
- Parhami, Farhad
Publication type:
Article
Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo.
Published in:
Journal of Cellular Biochemistry, 2011, v. 112, n. 6, p. 1673, doi. 10.1002/jcb.23082
By:
- Johnson, Jared S.;
- Meliton, Vicente;
- Kim, Woo Kyun;
- Lee, Kwang-Bok;
- Wang, Jeffrey C.;
- Nguyen, KhanhLinh;
- Yoo, Dongwon;
- Jung, Michael E.;
- Atti, Elisa;
- Tetradis, Sotirios;
- Pereira, Renata C.;
- Magyar, Clara;
- Nargizyan, Taya;
- Hahn, Theodore J.;
- Farouz, Francine;
- Thies, Scott;
- Parhami, Farhad
Publication type:
Article
Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress.
Published in:
Journal of Cellular Biochemistry, 2010, v. 111, n. 5, p. 1199, doi. 10.1002/jcb.22846
By:
- Kim, Woo-Kyun;
- Meliton, Vicente;
- Bourquard, Noam;
- Hahn, Theodore J.;
- Parhami, Farhad
Publication type:
Article
Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells.
Published in:
Cells (2073-4409), 2024, v. 13, n. 19, p. 1632, doi. 10.3390/cells13191632
By:
- Stappenbeck, Frank;
- Wang, Feng;
- Sinha, Satyesh K.;
- Hui, Simon T.;
- Farahi, Lia;
- Mukhamedova, Nigora;
- Fleetwood, Andrew;
- Murphy, Andrew J.;
- Sviridov, Dmitri;
- Lusis, Aldons J.;
- Parhami, Farhad
Publication type:
Article
Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling.
Published in:
Cells (2073-4409), 2019, v. 8, n. 10, p. 1297, doi. 10.3390/cells8101297
By:
- Stappenbeck, Frank;
- Wang, Feng;
- Tang, Liu-Ya;
- Zhang, Ying E.;
- Parhami, Farhad
Publication type:
Article
Inhibition of Hedgehog Signaling in Fibroblasts, Pancreatic, and Lung Tumor Cells by Oxy186, an Oxysterol Analogue with Drug-Like Properties.
Published in:
Cells (2073-4409), 2019, v. 8, n. 5, p. 509, doi. 10.3390/cells8050509
By:
- Wang, Feng;
- Stappenbeck, Frank;
- Parhami, Farhad
Publication type:
Article
Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer.
Published in:
Cell & Bioscience, 2022, v. 12, n. 1, p. 1, doi. 10.1186/s13578-022-00857-9
By:
- Tang, Liu-Ya;
- Spezia, Marie;
- Chen, Ting;
- Shin, Jee-Hye;
- Wang, Feng;
- Stappenbeck, Frank;
- Lebensohn, Andres M.;
- Parhami, Farhad;
- Zhang, Ying E.
Publication type:
Article
Oxy133, a novel osteogenic agent, promotes bone regeneration in an intramembranous bone-healing model.
Published in:
Journal of Tissue Engineering & Regenerative Medicine, 2017, v. 11, n. 5, p. 1490, doi. 10.1002/term.2047
By:
- Li, Andrew;
- Hokugo, Akishige;
- Segovia, Luis Andres;
- Yalom, Anisa;
- Rezzadeh, Kameron;
- Zhou, Situo;
- Zhang, Zheyu;
- Parhami, Farhad;
- Stappenbeck, Frank;
- Jarrahy, Reza
Publication type:
Article
A novel oxysterol promotes bone regeneration in rabbit cranial bone defects.
Published in:
Journal of Tissue Engineering & Regenerative Medicine, 2016, v. 10, n. 7, p. 591, doi. 10.1002/term.1799
By:
- Hokugo, Akishige;
- Sorice, Sarah;
- Parhami, Farhad;
- Yalom, Anisa;
- Li, Andrew;
- Zuk, Patricia;
- Jarrahy, Reza
Publication type:
Article
Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo.
Published in:
Journal of Orthopaedic Research, 2007, v. 25, n. 11, p. 1488, doi. 10.1002/jor.20437
By:
- Aghaloo, Tara L.;
- Amantea, Christopher M.;
- Cowan, Catherine M.;
- Richardson, Jennifer A.;
- Wu, Ben M.;
- Parhami, Farhad;
- Tetradis, Sotirios
Publication type:
Article

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