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- Title
Long-term histopathologic and IVUS evaluations of a novel coiled sheet stent in porcine carotid arteries.
- Authors
Kaneda, Hideaki; Ikeno, Fumiaki; Lyons, Jennifer; Rezaee, Mehrdad; Yeung, Alan C.; Fitzgerald, Peter J.
- Abstract
Carotid angioplasty with stent placement has been proposed as an alternative method for revascularization of carotid artery stenosis. A novel stent with a laser-cut, rolled sheet of Nitinol (EndoTex Interventional Systems, Inc., Cupertino, CA) has been developed to customize treatment of stenotic lesions in carotid arteries utilizing a single stent, designed to adapt to multiple diameters and to tapered or nontapered configurations. The purpose of this study is to evaluate the conformability and vascular response to a novel stent in a chronic porcine carotid model using serial three-dimensional intravascular ultrasound (IVUS) analysis as well as histological examination. Ten Yucatan pigs underwent stent implantation in both normal carotid arteries with adjunctive balloon angioplasty. Three-dimensional IVUS analysis was performed before stent implantation, after adjunctive balloon angioplasty, and at follow-up [1 month (n = 6), 3 months (n = 6), or 6 months (n = 8)]. Histological examination (injury score, percent plaque obstruction, and qualitative analysis) was also performed. All stents were successfully deployed and well apposed in different sized vessels (lumen area range: 19-30 mm(2)). Volumetric IVUS analysis showed no significant difference between the lumen areas before stent implantation and after adjunctive balloon angioplasty and no stent area change at each follow-up point compared to immediately postprocedure. Histological examination revealed minimal injury and neointimal hyperplasia at each follow-up point. In the chronic porcine carotid model, the novel stent system demonstrated good conformability, resulting in minimal vessel injury and neointimal formation.
- Subjects
CAROTID artery diseases; ANGIOPLASTY; INTRAVASCULAR ultrasonography; ARTERIAL stenosis; CEREBROVASCULAR disease; SURGICAL stents
- Publication
CardioVascular & Interventional Radiology, 2006, Vol 29, Issue 3, p413
- ISSN
0174-1551
- Publication type
journal article
- DOI
10.1007/s00270-005-0137-6