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- Title
Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis.
- Authors
Porru, Daniele; Leva, Fabio; Parmigiani, Alberto; Barletta, Davide; Choussos, Dimitrios; Gardella, Barbara; Daccò, Maria; Nappi, Rossella; Allegri, Massimo; Tinelli, Carmine; Bianchi, Carlo; Spinillo, Arsenio; Rovereto, Bruno
- Abstract
Introduction and hypothesis: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. Results: The score for urgency was reduced from 6.5 to 3.6 ( p = 0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 ( p = 0.0001). The average urine volume increased from 129.7 to 162 ml ( p < 0.0001), with a reduction in the number of voids in 24 h, from 14 to 11.6 ( p < 0.0001). The IC Symptom and Problem Index decreased from 25.7 to 20.3 ( p < 0.0001), and the Pain Urgency Frequency score, from 18.7 to 12.8 ( p < 0.0001). Conclusion: The treatment appeared to be effective and well tolerated in IC/BPS in this initial experience.
- Subjects
BLADDER diseases; HYALURONIC acid; CHONDROITIN sulfates; GLYCOSAMINOGLYCANS; INTERSTITIAL cystitis
- Publication
International Urogynecology Journal, 2012, Vol 23, Issue 9, p1193
- ISSN
0937-3462
- Publication type
Article
- DOI
10.1007/s00192-011-1546-5