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- Title
Identification of clinical predictive factors of oxaliplatin-induced chronic peripheral neuropathy in colorectal cancer patients treated with adjuvant Folfox IV.
- Authors
Vincenzi, Bruno; Frezza, Anna; Schiavon, Gaia; Spoto, Chiara; Addeo, Raffaele; Catalano, Vincenzo; Graziano, Francesco; Santini, Daniele; Tonini, Giuseppe
- Abstract
Purpose: Oxaliplatin-induced neuropathy is a dose-related side effect which occurs in almost 40 % of patients treated with oxaliplatin. Aim of the present study was to identify reliable clinical factors predicting its development and duration. Methods: One hundred sixty-nine completely resected colorectal cancer patients treated with adjuvant Folfox IV regimen were retrospectively included. The following pre-treatment clinical parameters were collected: hypocalcaemia, hypomagnesaemia, hypoalbuminaemia, anaemia, diabetes, chronic renal failure (CRF), folate deficiency, vitamin B deficiency, number of cycles received and habit to alcohol consumption. Incidence, grade (NCI-CTCAE v.3) and duration of neuropathy were recorded. Results: Incidence of neuropathy was found to be higher in patients with pre-treatment anaemia ( p = 0.001), hypoalbuminaemia ( p = 0.01) and hypomagnesaemia ( p = 0.001) as well in those with habit to alcohol consumption ( p = 0.003). Neuropathy durations were conversely associated with age, being longer in younger patients ( p = 0.03), and again with hypoalbuminaemia ( p = 0.04) and hypomagnesaemia ( p = 0.002). No correlation was found with gender, hypocalcaemia, diabetes and CRF. The correlation between vitamin B and folate levels and the development of neurotoxicity were not analysed because of the high number of missing data in the population. Conclusions: Age, anaemia, hypoalbuminaemia, hypomagnesaemia and alcohol consumption are reliable and easily assessable clinical factors predicting incidence and length of oxaliplatin-induced neuropathy.
- Subjects
OXALIPLATIN; PERIPHERAL neuropathy; COLON cancer patients; ADJUVANT treatment of cancer; DISEASE incidence; ANEMIA; CHRONIC kidney failure; VITAMIN B deficiency; THERAPEUTICS
- Publication
Supportive Care in Cancer, 2013, Vol 21, Issue 5, p1313
- ISSN
0941-4355
- Publication type
Article
- DOI
10.1007/s00520-012-1667-5