We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
US LI-RADS in surveillance for recurrent hepatocellular carcinoma after curative treatment.
- Authors
Huang, Hui; Cheng, Mei-Qing; He, Dan-Ni; Xian, Meng-Fei; Zeng, Dan; Wu, Shao-Hong; Li, Chao-Qun; Ruan, Si-Min; Li, Ming-De; Lin, Man-Xia; Lu, Ming-De; Kuang, Ming; Wang, Wei; Chen, Li-Da
- Abstract
Objectives: To investigate the performance of US LI-RADS in surveillance for recurrent hepatocellular carcinoma (RHCC) after curative treatment. Materials and methods: This study enrolled 644 patients between January 2018 and August 2018 as a derivation cohort, and 397 patients from September 2018 to December 2018 as a validation cohort. The US surveillance after HCC curative treatment was performed. The US LI-RADS observation categories and visualization scores were analyzed. Four criteria using US LI-RADS or Alpha-fetoprotein (AFP) as the surveillance algorithm were evaluated. The sensitivity, specificity, and negative predictive value (NPV) were calculated. Results: A total of 212 (32.9%) patients in derivation cohort and 158 (39.8%) patients in validation cohort were detected to have RHCCs. The criterion of US-2/3 or AFP ≥ 20 µg/L had higher sensitivity (derivation, 96.7% vs 92.9% vs 81.1% vs 90.6%; validation, 96.2% vs 90.5% vs 80.4% vs 89.9%) and NPV (derivation, 95.7% vs 93.3% vs 88.0% vs 91.8%; validation, 94.6% vs 89.4% vs 83.6% vs 89.0%), but lower specificity (derivation, 35.9% vs 48.2% vs 67.6% vs 51.9%; validation, 43.5% vs 52.7% vs 66.1% vs 54.0%) than criterion of US-2/3, US-3, and US-3 or AFP ≥ 20 µg/L. Analysis of the visualization score subgroups confirmed that the sensitivity (89.2–97.6% vs 81.0–83.3%) and NPV(88.4–98.0% vs 80.0–83.3%) of score A and score B groups were higher than score C group in criterion of US-2/3 in both two cohorts. Conclusions: In the surveillance for RHCC, US LI-RADS with AFP had a high sensitivity and NPV when US-2/3 or AFP ≥ 20 µg/L was considered a criterion. Clinical relevance statement: The criterion of US-2/3 or AFP ≥ 20 µg/L improves sensitivity and NPV for RHCC surveillance, which provides a valuable reference for patients in RHCC surveillance after curative treatment. Key Points: • US LI-RADS with AFP had high sensitivity and NPV in surveillance for RHCC when considering US-2/3 or AFP ≥ 20 µg/L as a criterion. • After US with AFP surveillance, patients with US-2/3 or AFP ≥ 20 µg/L should perform enhanced imaging for confirmative diagnosis. Patients with US-1 or AFP < 20 µg/L continue to repeat US with AFP surveillance. • Patients with risk factors for poor visualization scores limited the sensitivity of US surveillance in RHCC.
- Subjects
DISEASE risk factors
- Publication
European Radiology, 2023, Vol 33, Issue 12, p9357
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-023-09903-7