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- Title
Carotid stiffness and atherosclerotic risk: non-invasive quantification with ultrafast ultrasound pulse wave velocity.
- Authors
Zhu, Zheng-Qiu; Chen, Ling-Shan; Wang, Han; Liu, Fu-Ming; Luan, Yun; Wu, Lin-Lin; Liu, Niu; Wang, Pin; Huang, Hui
- Abstract
<bold>Objectives: </bold>To evaluate the value of ultrafast pulse wave velocity (ufPWV) for the quantitative assessment of carotid stiffness and its associated with atherosclerosis (AS) risk.<bold>Methods: </bold>The present study included 233 patients with hyperlipoidaemia (AS risk group) and 114 healthy adults as the control group. The carotid (n = 694) intima-media thickness (cIMT), pulse wave velocity-beginning of systole (PWV-BS) and pulse wave velocity-end of systole (PWV-ES) were measured on sample images. Differences, distributive characteristics and correlation evaluation were assessed in patients (ages 18-29, 30-39, 40-49, 50-59, 60-69 and ≥70) and carotids (control group vs AS risk group).<bold>Results: </bold>The cIMT, PWV-BS and PWV-ES increased with age; PWV-ES and cIMT showed an early significant increase in the 30-39 years group, whereas PWV-BS displayed a significant increase at 40-49 years compared with the 18- to 29-years group. Besides, PWV-ES correlated well with age compared with PWV-BS and cIMT. For carotid level, cIMT, PWV-BS and PWV-ES measurements were higher in the AS risk group compared with control. To compare the value of ufPWV and cIMT in early AS assessment, we subdivided groups into cIMT subgroups using a cut-off thickness of 0.050 cm. PWV-ES measurements were higher in the AS risk group compared with the control in the 0.040-0.050 cm (not thickened) and 0.051-0.060 cm (thickened) cIMT subgroups.<bold>Conclusions: </bold>Carotid ufPWV measurement at PWV-ES is a novel modality for the early diagnosis and quantitative assessment of arterial stiffness associated with atherosclerotic risk.<bold>Key Points: </bold>• ufPWV technique is real-time and well repeatable for assessing carotid stiffness • ufPWV measurements increase and correlate well with age • PWV-ES is a quantitative predictor for the early assessment of AS.
- Subjects
AGE distribution; ATHEROSCLEROSIS; CARDIOVASCULAR disease diagnosis; CARDIOVASCULAR system physiology; CAROTID artery; CAROTID artery diseases; CARDIAC contraction; LONGITUDINAL method; RESEARCH funding; ULTRASONIC imaging; EARLY diagnosis; CAROTID intima-media thickness
- Publication
European Radiology, 2019, Vol 29, Issue 3, p1507
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-018-5705-7