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- Title
Differences in myocardial strain between pectus excavatum patients and healthy subjects assessed by cardiac MRI: a pilot study.
- Authors
Lollert, André; Emrich, Tilman; Eichstädt, Jakob; Kampmann, Christoph; Abu-Tair, Tariq; Turial, Salmai; Düber, Christoph; Kreitner, Karl-Friedrich; Staatz, Gundula
- Abstract
<bold>Objectives: </bold>To evaluate differences in myocardial strain between pectus excavatum (PE) patients and healthy subjects (HS) assessed by cardiac MRI using the feature-tracking algorithm.<bold>Methods: </bold>Cardiac MRI was performed in 14 PE patients and 14 HS (9:5 male to female in each group; age 11-30 years) using a 3T scanner. Post-examination analysis included manual biventricular contouring with volumetry and ejection fraction measurement by two independent radiologists. Dedicated software was used for automated strain assessment.<bold>Results: </bold>In five of the PE patients, the right ventricular ejection fraction was slightly impaired (40-44 %). PE patients had a significantly higher left ventricular longitudinal strain (P=0.004), mid (P=0.035) and apical (P=0.001) circumferential strain as well as apical circumferential strain rate (P=0.001), mid right ventricular circumferential strain (P=0.008) and strain rate (P=0.035), and apical right ventricular circumferential strain (P=0.012) and strain rate (P=0.044) than HS. The right ventricular longitudinal strain and strain rate did not differ significantly between PE patients and HS.<bold>Conclusions: </bold>Myocardial strain differs significantly between PE patients and HS. Higher myocardial strain in the mid and apical ventricles of PE patients indicates a compensation mechanism to enhance ventricular output against basal sternal compression.<bold>Key Points: </bold>• The right ventricle is frequently affected by the pectus excavatum deformity. • Cardiac MRI revealed differences in myocardial strain in pectus excavatum patients. • Pectus excavatum patients exhibited higher strain in the mid/apical ventricles. • A compensation mechanism to enhance ventricular output against sternal compression is possible.
- Subjects
PECTUS excavatum; CARDIAC magnetic resonance imaging; INTRACLASS correlation; MYOCARDITIS; PATIENTS; THERAPEUTICS; HEART ventricle diseases; HEART ventricles; RIGHT heart ventricle; MAGNETIC resonance imaging; MYOCARDIUM; PILOT projects; HUMAN research subjects; DISEASE complications; DIAGNOSIS; PHYSIOLOGY
- Publication
European Radiology, 2018, Vol 28, Issue 3, p1276
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-5042-2