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- Title
Coronary CT angiography characteristics of OCT-defined thin-cap fibroatheroma: a section-to-section comparison study.
- Authors
Yang, Dong Hyun; Kang, Soo-Jin; Koo, Hyun Jung; Chang, Mineok; Kang, Joon-Won; Lim, Tae-Hwan; Baek, Seunghee; Han, Seungbong; Lee, Pil Hyung; Roh, Jae-Hyung; Ahn, Jung-Min; Park, Duk-Woo; Lee, Seung-Whan; Lee, Cheol Whan; Park, Seong-Wook; Park, Seung-Jung; Mintz, Gary S.; Kim, Young-Hak
- Abstract
<bold>Objectives: </bold>To evaluate whether plaque characteristics as assessed by coronary computed tomography angiography (CCTA) were associated with the presence of a thin-cap fibroatheroma (TCFA)-a precursor of plaque rupture-defined by optical coherence tomography (OCT) in a section-to-section-level comparison.<bold>Methods: </bold>From 28 symptomatic patients, 31 coronary lesions were evaluated on 727 cross-sections co-registered by both CCTA and OCT. CCTA plaque characteristics included low attenuation plaque (LAP, <30 HU), napkin ring sign (NRS), positive remodelling (PR, remodelling index ≥1.10), and spotty calcification and plaque area and plaque burden. By OCT, presence of TCFA, lumen area and arc of lipid were determined.<bold>Results: </bold>OCT revealed a TCFA in 69 (9.4%) sections from 19 (61.2 %) lesions. In per-section analysis, OCT-TCFA showed higher frequency of CCTA-detected LAP (58.0% vs. 18.5%), NRS (31.9% vs. 8.8%) and PR (68.1% vs. 48.0%) and greater plaque burden (70.6% vs. 61.9%) as compared to sections without OCT-TCFA (all p < 0.05). In multivariable analysis, LAP (odds ratio [OR] 4.05, p < 0.001) and NRS (OR 2.47, p = 0.005) were associated with OCT-TCFA. CCTA-measured lumen area correlated well with OCT-measured lumen area (R = 0.859, limits of agreement -0.5 ± 3.7 mm2).<bold>Conclusions: </bold>LAP and NRS in CCTA were associated with the presence of OCT-defined TCFA in a section-to-section comparison.<bold>Key Points: </bold>• CT-defined LAP and NRS were associated with OCT-defined TCFA • OCT-TCFA showed higher frequency of LAP, NRS, PR and greater plaque burden • Non-calcified plaque area was correlated with OCT-measured lipid arc.
- Subjects
COMPUTED tomography; ATHEROSCLEROTIC plaque; OPTICAL coherence tomography; CORONARY disease; MEDICAL radiography; ATHEROSCLEROSIS; ORGAN rupture; CORONARY angiography; CALCINOSIS; ODDS ratio
- Publication
European Radiology, 2018, Vol 28, Issue 2, p833
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-4992-8