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- Title
Lafora's disease.
- Authors
Ramón y Cajal, S.; Blanes, A.; Martinez, A.; Sáenz, E.; Gutierrez, M.
- Abstract
Cerebral biopsies of three patients aged 22, 18 and 16 years with myoclonic epilepsy contained Lafory bodies. Two were a brother and sister of consanguineous parents. The Lafora bodies occurred in most neurons but not in glial cells. The ultrastructure of these bodies showed a fibrillar and granular material in the perikaryon and neuropile. In some neurons small Lafora bodies were delimited by a double membrane, suggesting that in early phases they have a membrene which disappears when they become more developed. Other non-specific neuron alterations are described. One of the cases presented in the liver PAS positive bodies of a structure different from the Lafora bodies.
- Publication
Acta Neuropathologica, 1974, Vol 30, Issue 3, p189
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/BF00688920