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- Title
Decreased beta cell function and insulin sensitivity contributed to increasing fasting glucose in Chinese.
- Authors
Bi, Yan; Zhu, Dalong; Jing, Yali; Hu, Yun; Feng, Wenhuan; Shen, Shanmei; Tong, Guoyu; Shen, Xujun; Yu, Tingting; Song, Dan; Yang, Donghui
- Abstract
To evaluate the role of insulin resistance and beta cell function to increasing fasting plasma glucose (FPG), 1,272 Chinese subjects (18-80 years of age) were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), combined glucose intolerance (CGI), and type 2 diabetes mellitus (T2DM) according to oral glucose tolerance test. Insulin sensitivity was measured by Matsuda index (ISI) and homeostasis model assessment of insulin resistance (1/HOMA-IR); β-cell function adjusted by insulin sensitivity was assessed from disposition index (DI) at basal DI (homeostasis model assessment of β-cell function (HOMA-B) × [1/HOMA-IR]), early-phase DI (the ratio of total insulin AUC and total glucose AUC during 0-30 min of the OGTT (InsAUC/GluAUC) × ISI) and total DI (the ratio of total insulin AUC and total glucose AUC during 0-120 min of the OGTT (InsAUC/GluAUC) × ISI). Compared with NGT, in IFG, ISI (−23%), DI (−38%), DI (−30%), and DI (−31%) were decreased significantly. As the FPG increased across categories classified by FPG levels from NGT → IFG → T2DM with 2 h PG < 7.8 mmol/l, ISI, DI, DI and DI showed decline beginning from normal range of FPG, compared with the reference category of FPG < 4.0 mmol/l. Correlation analysis showed that ISI and DI were correlated inversely with FPG concentration ( r = −0.242 for ISI, r = −0.933 for DI, r = −0.806 for DI, r = −0.817 for DI; P < 0.001). Both the impairment of beta cell function and insulin sensitivity started at the low point of FPG within the normoglycemic range and contributed to the deterioration of fasting glucose.
- Subjects
CHINA; PANCREATIC beta cells; TYPE 2 diabetes; BLOOD sugar; HOMEOSTASIS; PREPROCEDURAL fasting; HEALTH of Chinese people
- Publication
Acta Diabetologica, 2012, Vol 49, p51
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-010-0194-4