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- Title
Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes.
- Authors
Ikegami, T.; Calaor, A. B.; Miranda, M. E.; Niikura, M.; Saijo, M.; Kurane, I.; Yoshikawa, Y.; Morikawa, S.
- Abstract
Summary. We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.
- Subjects
PHILIPPINES; EBOLA virus; VIRUS diseases; NUCLEOTIDE sequence; GENETIC transcription; NUCLEOTIDES; GLYCOPROTEINS; AMINO acids
- Publication
Archives of Virology, 2001, Vol 146, Issue 10, p2021
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s007050170049