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- Title
Anti-Inflammatory and Antiproteolytic Properties of 2-[Acyl-N-(Substituted Benzylidene)hydrazino]5-phenyltetrazoles.
- Authors
Raman, Krishna; Parmar, Surendra S.; Kumar, Sushil; Brumleve, Stanley J.
- Abstract
Ten 2-[acyl-N-(substituted benzylidene)hydrazíno]5-phenyltetrazoles were synthesized, characterized and evaluated for anti-inflammatory and antiproteolytic activity. The protection afforded by these tetrazoles at a dose of 100 mg/kg i.p., against carrageenin-induced edema in rats, ranged from 11 to 46%. Oxyphenbutazone (40 mg/kg i.p.), and hydrocortisone (10 mg/kg i.p.), used as reference drugs, exhibited protection of 54 and 47%, respectively. The antiproteolytic activity of these tetrazoles, as reflected by their ability to inhibit trypsin-induced hydrolysis of bovine serum albumin, ranged from 17 to 57%. The antiproteolytic activity was found to be unrelated to the anti-inflammatory activity possessed by these tetrazoles. Copyright © 1978 S. Karger AG, Basel
- Publication
Pharmacology, 1978, Vol 17, Issue 1, p56
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000136835