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- Title
Bactericidal Effect of Levofloxacin on Strains with Equal Susceptibility in anin vitro Urinary Bladder Model.
- Authors
Takahashi, Satoshi; Sano, Masato; Nishimura, Masahiro; Matsukawa, Masanori; Mikami, Midori; Hirose, Takaoki; Tsukamoto, Taiji
- Abstract
The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 107 CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simulated to its clinically achievable urinary levels at the recommended dosage (100 mg 3 times daily). An isolate of P. aeruginosa for which the MIC of LVFX was 16 µg/ml was completely eradicated after 10 h of exposure to LVFX. On the other hand, 40 h of exposure to LVFX were required for complete eradication of an isolate of E. faecalis with equal susceptibility, although the bacterial count was rapidly reduced to 102 CFU/ml in the early phase of the exposure. It was concluded that LVFX exerts a more potent bactericidal effect on P. aeruginosa than on E. faecalis despite a similar susceptibility of these organisms to LVFX.
- Publication
Chemotherapy (0009-3157), 1998, Vol 44, Issue 5, p337
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000007133