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- Title
Interaction of Beta-Lactam Antibiotics with the Penicillin-Binding Proteins of Penicillin-Resistant Streptococcus pneumoniae.
- Authors
Ikeda, Fumiaki; Yokota, Yoshiko; Ikemoto, Akiko; Teratani, Noriko; Shimomura, Kyoichi; Kanno, Harushige
- Abstract
The binding of five structurally diverse β-lactam antibiotics to penicillin-binding proteins (PBPs) of two clinical isolates of Streptococcus pneumoniae resistant to penicillin G was compared with that of a susceptible strain. A common feature of the PBP patterns of the resistant strains was the absence of PBP la detected in the susceptible strain. For each β-lactam antibiotic tested, there appeared to be significant decreases in the affinity for BPB 1b, 2a and 2b of the resistant strains. We attempted to evaluate a quantitative correlation between the antibacterial activity of the drugs for three strains and their affinity for the various PBPs. A close correlation was found between the minimum inhibitory concentrations and the affinity for PBP 2a, but not for any of the other PBPs. Copyright © 1995 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1995, Vol 41, Issue 3, p159
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000239338