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- Title
In vitro Interactions of Amikacin and Beta-Lactam Antibiotics against Amikacin-Resistant Gram-Negative Bacilli.
- Authors
Alvarez, Salvador; Jones, Mary; Holtsclaw-Berk, Shirley; Berk, Steven L.
- Abstract
We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combination by the checkerboard technique, while amikacin-cefoperazone was the most active combination by the time-killing curve technique against Pseudomonas aeruginosa. Discrepancies were found between the results of the two methods used. Copyright © 1988 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1988, Vol 34, Issue 2, p107
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000238556