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- Title
Original article. Peripheral deletion of γδ T cells in haemodialysis patients.
- Authors
Matsumoto, Y; Shinzato, T; Takai, I; Nishimoto, A; Nakai, S; Sakai, T; Amano, I; Maeda, K
- Abstract
Many patients with end-stage renal disease have altered host defenses against infectious agents. We have demonstrated that T cells, which play an important role in the immunological response, may undergo apoptosis by the Fas system in uraemia. To elucidate whether γδ T cells, which function as a first defense against intracellular pathogens, are altered in number or characteristics in dialysis patients surface expressions of TCR, LFA-1 and Fas antigen on peripheral T cells were examined by immunofluorescence analysis. We demonstrated the proportions of peripheral γδ T cells are altered significantly in haemodialysis (HD) patients. Interestingly, there were marked differences in the levels of expression of LFA-1 and Fas antigen between the two types of T cells. Moreover both the expression of LFA-1 and that of Fas antigen were enhanced significantly in HD patients compared with normal controls. These results suggest that circulating γδ T cells may be susceptible to activation-induced cell death in comparison with αβ T cells in uraemic environments.
- Publication
Nephrology Dialysis Transplantation, 1998, Vol 13, Issue 11, p2861
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/13.11.2861