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- Title
In-vitro activity of clinafloxacin (CI-960) and PD 131628-2 against anaerobic bacteria.
- Authors
Wexler, Hannah M.; Molitoris, Eric; Reeves, Denise; Finegold, Sydney M.; Wexler, H M; Molitoris, E; Reeves, D; Finegold, S M
- Abstract
The antimicrobial activities of two new quinolones, CI-960 and PD 131628-2 were determined against 339 strains of anaerobic bacteria and compared to cefoxitin, imipenem and metronidazole. The NCCLS-approved Wadsworth agar dilution technique with Brucella-lysed blood agar was used throughout the study. Breakpoints of the new quinolones are 2 mg/L, and breakpoints for cefoxitin, imipenem and metronidazole are 32, 8 and 16 mg/L, respectively. CI-960 displayed excellent activity, inhibiting all strains tested at 1 mg/L. PD 131628-2 inhibited 94% of Bacteroides fragilis, 75% of other B. fragilis group isolates, 87% of Prevotella spp, 79% of the Fusobacterium mortiferum-varium group, 74% of non-sporing gram-positive bacilli, and 89-100% of Clostridium spp other than Clostridium difficile at 2 mg/L. None of the eight strains of C. difficile was inhibited at 2 mg/L although they were inhibited at 4 mg/L. PD 131628-2 inhibited all strains of other Bacteroides spp, Porphyromonas spp, and Fusobacterium nucleatum at < or = 1 mg/L.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1994, Vol 34, Issue 4, p579
- ISSN
0305-7453
- Publication type
journal article