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- Title
Temocillin (BRL 17421): in-vitro antibacterial activity and susceptibility to beta-lactamases.
- Authors
Phillips, Ian; King, Anna; Shannon, Kevin; Warren, Christine; Phillips, I; King, A; Shannon, K; Warren, C
- Abstract
Temocillin, a 6-α-methoxypenicillin, was active against enterobacteria with MICs mostly in the range 1 to 16mg/l. It was also active against (MICs 0·5–4 mg/l) and (MICs 0·03–8 mg/l), including /Mactamase producers. The compound was not very active against Pseudomonas aeruginosa (MICs 128 to > 512 mg/l) and most other pseudo-monads, though it was active against and (MICs 1–4 mg/1). Temocillin had variable activity against Acinetobacter (MICs 1–256 mg/1). It was also variably active against Gram-negative anaerobes, but less active than ampicillin. However, it had poor activity against most Gram-positive organisms, whether aerobes or anaerobes. Temocillin was resistant to hydrolysis by all the β-lactamases tested except for the enzymes from an isolate of and a -like organism whose β-lactamases hydrolysed temocillin slowly (at about 1% of the rate of hydrolysis of ampicillin).
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1982, Vol 10, Issue 4, p271
- ISSN
0305-7453
- Publication type
journal article