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- Title
ASSESSMENT OF INFLAMMATORY STATUS IN INTERSTITIAL VERSUS BACTERIAL PNEUMONIA.
- Authors
Avram, Dora Denisa; Niţu, Cristina-Ana-Maria; Todea, Stefania; Şuşca, Andreea; Marginean, Oana
- Abstract
Introduction: Pneumonia in children is a major health problem, being a leading cause of morbidity and mortality in children under 5 years old. Although pneumonia-related deaths occur predominantly in developing countries, the impact of this disease remains meaningful worldwide and has important consequences for both public health and the costs associated with specialized medical care. Case Report: A retrospective study was performed using data collected from 138 patients, aged between one month and 17 years old, admitted to the Pediatric Department I within the Târgu-Mureş Emergency County Hospital (01/01/2019-31/12/2023). The patients from our study were divided into 2 groups: the 1st group - 69 children with interstitial pneumonia and the 2nd group - 69 children with bacterial pneumonia. Inclusion criteria were represented by children admitted to the Pediatric Department presenting respiratory symptoms such as wheezing, cough, fever, rhinoreea. Exclusion criteria involved patients diagnosed with other infectious or non-infectious pathologies. Analyzed variables included age, gender, weight, diagnosis upon admission, CBC (complete blood count), levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), as well as platelet-to-lymphocyte ratio (PLR), evolution and length of hospital stay. Discussions : The average age of the children from our study was 26 months, with an average weight of 11.7 kg. Younger patients were more frequently diagnosed with interstitial pneumonia (p < 0.001). Most of the patients included into our study were represented by boys (56.5%). The analysis and comparison of laboratory parameters revealed significantly higher values of PCR (p<0, 01), ESR (p<0, 01), leukocyte count (p<0, 01), neutrophils (p<0, 01), as well as NLR (p<0, 01) and PLR (p<0, 01) in patients with bacterial pneumonia. Patients diagnosed with interstitial pneumonia had significantly higher values of erythrocyte count (p = 0, 02), lymphocytes (p<0, 01), eosinophils (p<0, 001), and basophils (p<0, 01). Patients diagnosed with bacterial pneumonia exhibited an average hospitalization length of 6 days (3 to 32 days), while in those with interstitial pneumonia the hospitalization was shorter: 4 days (1 to 9 days). Conclusions: Early determination of the NLR and PLR, both defining the subclinical inflammatory status, is essential for promptly diagnosing and preventing potential complications in pediatric pneumonia. Furthermore, acute phase reactants play an important role in screening and differential diagnosis between bacterial and interstitial pneumonia in children.
- Subjects
ROMANIA; PNEUMONIA; INTERSTITIAL lung diseases; CONFERENCES &; conventions; INFLAMMATION; BIOMARKERS; CHILDREN
- Publication
Acta Marisiensis. Seria Medica, 2024, Vol 70, p309
- ISSN
2668-7755
- Publication type
Article