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- Title
Meme kanseri trucut iğne biyopsi ve rezeksiyon materyallerinde yeni moleküler sınıflama, tanı ve hormon reseptörlerinin durumu tutarlı mı?
- Authors
Karakaya, Yeliz Arman; Yılmaz, Sevda; Karabaş, Hande
- Abstract
Purpose: The aim of this study was to evaluate the the concordance rate of molecular subtypes histological grade, estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) levels between the diagnostic biopsy and resection materials in breast cancer, in the light of the literature. Materials and methods: Trucut needle biopsy (TNB) and resection materials of 64 cases, diagnosed at Department of Pamukkale University Medical Faculty Pathology, between 2018 May and 2020 November were included in this study. Tumor type, degree and pathological information on ER, PgR, HER2, Ki-67, immunohistochemically and HER2 status by molecular FISH method were analyzed retrospectively. Results: : Concordance rate between resection specimens and trucut needle biopsy is 93.75%. The concordance rates for ER, PgR, HER are 89% (kappa, 0.685, p<0.001), 81.8% (kappa, 0.645, p<0.001), 95% (kappa=8.68, p<0.001), respectively. HER2 concordance rates is better than ER and PgR receptor concordance rates. In Ki-67, a moderate agreement (kappa, 0.447, p<0.001) was observed at a rate of 79%. A good agreement 79% (kappa, 0.637, p<0.001) was found in the grade comparison. Concordance rate between molecular classification was 93% and very good agreement (kappa, 0.882, p<0.001) was found. Luminal A is the most common type and the concordance rate is 97%. Conclusion: A high agreement was observed between diagnostic biopsy and resection materials. It was concluded that TIBs are reliable materials for determining the histopathological characteristics of the tumor, and studying the immunohistochemical staining of ER, PgR, HER2, Ki-67, which are important in diagnosis, treatment and prognosis. In addition, Ki-67 has been found to be important in molecular subtyping of HER2 negative tumors.
- Subjects
ESTROGEN receptors; PROGESTERONE receptors; BREAST cancer; NEEDLE biopsy; MEDICAL literature
- Publication
Pamukkale Medical Journal, 2021, Vol 14, Issue 2, p416
- ISSN
1309-9833
- Publication type
Article
- DOI
10.31362/patd.846610